Targeted osmotic lysis of cancer cells

专利名称：Targeted osmotic lysis of cancer cells发明人：Paul, Dennis J.,Gould, Harry J.申请号：AU2012284010申请日：20120719

公开号：AU2012284010A1公开日：20140306

摘要：A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gatedsodium channels (VGSCs) has been developed that uses a combined therapy of a drugthat blocks sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase) that is thenfollowed by an activation of VGSCs, for example, by electrical or pharmacologicalstimulation. Activation of VGSCs conducts sodium into the cancer cells in much greateramounts than non-cancer cells. Water follows this sodium gradient into the cancer cells,causing swelling and lysis. Because non-cancerous cells do not over-express VGSCs, lesssodium and less water will enter the cells, and the non-cancerous cells will not lyse. Thismethod is applicable to all cells that over-express VGSCs, including, but not limited to,highly invasive breast cancer, prostate cancer, small cell lung cancer, non-small cell lungcarcinoma, lymphoma, mesothelioma, neuroblastoma, and cervical cancer.

申请人：Board of Supervisors of Louisiana State University and Agricultural andMechanical College

代理人：Phillips Ormonde Fitzpatrick

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